BRENDA - Enzyme Database show
show all sequences of 1.13.11.71

Cellular localization of ?-carotene 15,15 oxygenase-1 (BCO1) and beta-carotene 9,10 oxygenase-2 (BCO2) in rat liver and intestine

Raghuvanshi, S.; Reed, V.; Blaner, W.S.; Harrison, E.H.; Arch. Biochem. Biophys. 572, 19-27 (2015)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
additional information
subcellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, overview
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-beta-carotene + O2
Rattus norvegicus
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
A3KN98
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
intestine
-
Rattus norvegicus
-
liver
BCO2 is highly expressed in hepatocytes and mucosal epithelium
Rattus norvegicus
-
McArdle RH7777 cell
-
Rattus norvegicus
-
additional information
cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO2 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-beta-carotene + O2
-
744161
Rattus norvegicus
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
additional information
subcellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, overview
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-beta-carotene + O2
Rattus norvegicus
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
intestine
-
Rattus norvegicus
-
liver
BCO2 is highly expressed in hepatocytes and mucosal epithelium
Rattus norvegicus
-
McArdle RH7777 cell
-
Rattus norvegicus
-
additional information
cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO2 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-beta-carotene + O2
-
744161
Rattus norvegicus
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
BCO2 catalyzes eccentric cleavage of both provitamin and non-provitamin A carotenoids which results in the formation of apo-carotenoids such as beta-apo-10' carotenal and beta-ionone
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
BCO2 catalyzes eccentric cleavage of both provitamin and non-provitamin A carotenoids which results in the formation of apo-carotenoids such as beta-apo-10' carotenal and beta-ionone
Rattus norvegicus
Other publictions for EC 1.13.11.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Guo
Ablation of beta,beta-caroten ...
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74-82
2017
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745345
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Substrate specificity of puri ...
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11
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2
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Raghuvanshi
Cellular localization of ?-ca ...
Rattus norvegicus
Arch. Biochem. Biophys.
572
19-27
2015
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Purification and characteriza ...
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727965
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Liu
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Lotus japonicus
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727353
Lobo
BCDO2 acts as a carotenoid sca ...
Danio rerio, Homo sapiens
Development
139
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2012
-
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3
3
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719151
Kim
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Homo sapiens
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2011
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1
1
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1
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1
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1
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5
1
1
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1
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1
1
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A mitochondrial enzyme degrade ...
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FASEB J.
25
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2011
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Amengual
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2011
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16
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