BRENDA - Enzyme Database show
show all sequences of 1.13.11.71

BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway

Lobo, G.P.; Isken, A.; Hoff, S.; Babino, D.; von Lintig, J.; Development 139, 2966-2977 (2012)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4-oxo-N-(4-hydroxyphenyl)-all-trans-retinamide
-
Danio rerio
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Danio rerio
5739
-
mitochondrion
-
Homo sapiens
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
bcdo2 is expressed in the developing zebrafish
Danio rerio
-
T-47D cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-carotene + O2
-
727353
Homo sapiens
10'-apo-carotenal + beta-ionone
-
-
-
?
beta-carotene + O2
-
727353
Danio rerio
10'-apo-carotenal + beta-ionone
-
-
-
?
canthaxanthin + O2
-
727353
Homo sapiens
?
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-oxo-N-(4-hydroxyphenyl)-all-trans-retinamide
-
Danio rerio
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Danio rerio
5739
-
mitochondrion
-
Homo sapiens
5739
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
bcdo2 is expressed in the developing zebrafish
Danio rerio
-
T-47D cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-carotene + O2
-
727353
Homo sapiens
10'-apo-carotenal + beta-ionone
-
-
-
?
beta-carotene + O2
-
727353
Danio rerio
10'-apo-carotenal + beta-ionone
-
-
-
?
canthaxanthin + O2
-
727353
Homo sapiens
?
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
targeted knockdown of BCDO2 results in anemia at larval stages. Marker gene analysis and staining for hemoglobin revealed that erythropoiesis is not impaired but that erythrocytes undergo apoptosis in BCDO2- deficient larvae
Danio rerio
malfunction
knockdown of Bcdo2 by siRNA treatment in T47D cells enhances reactive oxygen species production upon carotenoid treatment. Bcdo2 siRNA-treated T47D cells show initiation of apoptosis evidenced by caspase 3 and PARP1 cleavage as established by immunoblot analyses
Homo sapiens
physiological function
BCDO2 dictates apoptotic responses to carotenoids and synthetic retinoids in human cancer cells
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
targeted knockdown of BCDO2 results in anemia at larval stages. Marker gene analysis and staining for hemoglobin revealed that erythropoiesis is not impaired but that erythrocytes undergo apoptosis in BCDO2- deficient larvae
Danio rerio
malfunction
knockdown of Bcdo2 by siRNA treatment in T47D cells enhances reactive oxygen species production upon carotenoid treatment. Bcdo2 siRNA-treated T47D cells show initiation of apoptosis evidenced by caspase 3 and PARP1 cleavage as established by immunoblot analyses
Homo sapiens
physiological function
BCDO2 dictates apoptotic responses to carotenoids and synthetic retinoids in human cancer cells
Homo sapiens
Other publictions for EC 1.13.11.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745596
Guo
Ablation of beta,beta-caroten ...
Mus musculus
J. Nutr. Biochem.
46
74-82
2017
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2
2
-
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-
745345
Dela Sena
Substrate specificity of puri ...
Gallus gallus, Homo sapiens
J. Biol. Chem.
291
14609-14619
2016
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2
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11
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2
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2
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3
3
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745753
Gong
Mitochondrial beta-carotene 9 ...
Homo sapiens
Mol. Cancer Res.
14
966-975
2016
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1
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2
3
3
2
-
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744160
Kim
Tissue- and sex-specific effe ...
Mus musculus, Mus musculus C57BL/6
Arch. Biochem. Biophys.
572
11-18
2015
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744161
Raghuvanshi
Cellular localization of ?-ca ...
Rattus norvegicus
Arch. Biochem. Biophys.
572
19-27
2015
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2
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1
1
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744574
Wei
Purification and characteriza ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ULI3
Biotechnol. Lett.
37
1993-1998
2015
3
1
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3
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8
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3
744613
Jlali
Nutrigenetics of carotenoid m ...
Gallus gallus
Br. J. Nutr.
111
2079-2088
2014
-
-
1
-
1
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746290
Li
Inactivity of human beta,beta ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6
Proc. Natl. Acad. Sci. USA
111
10173-10178
2014
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2
-
2
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10
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11
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2
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2
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5
5
-
-
-
727965
Amengual
Two carotenoid-oxygenases cont ...
Mus musculus
J. Biol. Chem.
288
34081-34096
2013
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1
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1
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728057
Liu
Carotenoid cleavage dioxygenas ...
Lotus japonicus
J. Exp. Bot.
64
1967-1981
2013
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727353
Lobo
BCDO2 acts as a carotenoid sca ...
Danio rerio, Homo sapiens
Development
139
2966-2977
2012
-
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1
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3
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3
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719151
Kim
Production of beta-apo-10'-car ...
Homo sapiens
Biotechnol. Lett.
33
1195-1200
2011
-
1
1
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1
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1
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5
1
1
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1
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1
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1
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5
1
1
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1
1
719438
Amengual
A mitochondrial enzyme degrade ...
Mus musculus
FASEB J.
25
948-959
2011
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1
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1
1
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728552
Amengual
Beta-carotene reduces body adi ...
Mus musculus
PLoS ONE
6
e20644
2011
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714616
Vage
A nonsense mutation in the bet ...
Ovis aries
BMC Genet.
11
10
2010
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720559
Ledger
Modified CAROTENOID CLEAVAGE D ...
Actinidia chinensis
New Phytol.
188
803-813
2010
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720702
Auldridge
Characterization of three memb ...
Arabidopsis thaliana
Plant J.
45
982-993
2006
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720152
Lindqvist
Cell type-specific expression ...
Homo sapiens
J. Histochem. Cytochem.
53
1403-1412
2005
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719823
Schwartz
The biochemical characterizati ...
Arabidopsis thaliana
J. Biol. Chem.
279
46940-46945
2004
1
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719806
Kiefer
Identification and characteriz ...
Homo sapiens, Mus musculus
J. Biol. Chem.
276
14110-14116
2001
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