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Literature summary for 1.13.11.71 extracted from

  • Amengual, J.; Lobo, G.; Golczak, M.; Li, H.; Klimova, T.; Hoppel, C.; Wyss, A.; Palczewski, K.; Von Lintig, J.
    A mitochondrial enzyme degrades Carotenoids and protects against oxidative stress (2011), FASEB J., 25, 948-959.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q99NF1
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-

Synonyms

Synonyms Comment Organism
Bcdo2
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 Mus musculus
BCO2
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 Mus musculus
beta,beta-carotene 9',10'-oxygenase
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 Mus musculus

General Information

General Information Comment Organism
physiological function in enzyme-deficient mice, carotenoid homeostasis is abrogated, and carotenoids accumulate in several tissues. In hepatic mitochondria, accumulated carotenoids induce key markers of mitochondrial dysfunction, such as manganese superoxide dismutase, 9fold, and reduce rates of ADP-dependent respiration by 30%. This impairment is associated with an 8- to 9fold induction of phosphor-MAP kinase and phosphor-AKT, markers of cell signaling pathways related to oxidative stress and disease Mus musculus