Literature summary for 1.13.11.65 extracted from

Voolstra, O.; Oberhauser, V.; Sumser, E.; Meyer, N.E.; Maguire, M.E.; Huber, A.; von Lintig, J.
NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors (2010), J. Biol. Chem., 285, 2130-2139.

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VFS2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
eye	gene expression is eye-dependent and is activated as adownstream target of the eyeless/pax6 and sine oculis master control genes for eye development	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
zeaxanthin + O2	-	Drosophila melanogaster	(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal	beta-carotene is first converted to zeaxanthin and then cleaved by the enzmye to directly yield 3-hydroxy-retinal	?

Synonyms

Synonyms	Comment	Organism
NinaB	-	Drosophila melanogaster

Expression

Organism	Comment	Expression
Drosophila melanogaster	gene expression is eye-dependent and is activated as a downstream target of the eyeless/pax6 and sine oculis master control genes for eye development	up

General Information

General Information	Comment	Organism
physiological function	mutants show no photophobic behavior indicating that NinaB is essential for larval light perception. Enzyme expression and chromophore production is governed by eyeless and so, major control genes for eye development	Drosophila melanogaster

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Release 2023.1 (January 2023)