Literature summary for 1.13.11.54 extracted from

Milaczewska, A.; Kot, E.; Amaya, J.; Makris, T.; Zaj?c, M.; Korecki, J.; Chumakov, A.; Trzewik, B.; Kedracka-Krok, S.; Minor, W.; Chruszcz, M.; Borowski, T.
On the structure and reaction mechanism of human acireductone dioxygenase (2018), Chemistry, 24, 5225-5237 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 (DE3) codon Plus RIPL cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme in complex with selenomethionine, sitting drop vapor diffusion method, using 1:0.8 sodium acetate (0.1 M), ammonium sulfate (2.0 M pH 4.5)	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	dependent on	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2	Homo sapiens	-	4-(methylsulfanyl)-2-oxobutanoate + formate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BV57	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA resin column chromatography and Superdex 200 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2	-	Homo sapiens	4-(methylsulfanyl)-2-oxobutanoate + formate	-	?
1,2-dihydroxy-hex-1-en-3-one + O2	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Fe-ARD	-	Homo sapiens

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Release 2023.1 (January 2023)