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Literature summary for 1.13.11.53 extracted from

  • Chu, Y.D.; Lai, H.Y.; Pai, L.M.; Huang, Y.H.; Lin, Y.H.; Liang, K.H.; Yeh, C.T.
    The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine (2019), Cell Death Dis., 10, 240 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.53

Application

Application Comment Organism
medicine the enzyme level positively associates with postoperative recurrence-free survival in patients with hepatocellular carcinoma Homo sapiens

Protein Variants

Protein Variants Comment Organism
E94A the mutant has an increased percentage of apoptotic cells similar to those expressing wild type enzyme Homo sapiens
H133A the mutation at the metal-binding site abolishes both functions of the enzyme in cell growth inhibition and apoptosis enhancement Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 Homo sapiens
-
 3-(methylsulfanyl)propanoate + formate + CO
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BV57
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2
-
 Homo sapiens 3-(methylsulfanyl)propanoate + formate + CO
-
 ?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
acireductone dioxygenase 1
-
 Homo sapiens
ADI1
-
 Homo sapiens
MTCBP1
-
 Homo sapiens
Sip-L
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens there is a significant reduction of enzyme, either in protein or mRNA level, in hepatocellular carcinoma tissues down

General Information

General Information Comment Organism
physiological function enzyme expression promotes 5'-methylthioadenosine cycle to increase S-adenosylmethionine levels, which alter genome-wide promoter methylation profiles, resulting in altered gene expression and hepatocellular carcinoma growth suppression Homo sapiens