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Literature summary for 1.13.11.52 extracted from

  • Roehrig, U.F.; Reynaud, A.; Majjigapu, S.R.; Vogel, P.; Pojer, F.; Zoete, V.
    Inhibition mechanisms of indoleamine 2,3-dioxygenase 1 (IDO1) (2019), J. Med. Chem., 62, 8784-8795 .
    View publication on PubMed
Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

General Stability

General Stability Organism
the enzyme is unstable in the presence of reductants and oxygen and heme-binding ligands increase its stability Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide i.e. Incyte-5l Homo sapiens
4-chloro-2-(1H-1,2,3-triazol-4-yl)phenol i.e. MMG-0358 Homo sapiens
4-phenylimidazole
-
 Homo sapiens
N-(4-chlorophenyl)-2H-1,2,3-triazol-4-amine i.e. Vertex-AT Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO1
-
 Homo sapiens
indoleamine 2,3-dioxygenase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme heme enzyme Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the rate limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging Homo sapiens
physiological function the enzyme catalyzes the rate limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging Homo sapiens