Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.52 extracted from

  • Kwon, M.; Ko, S.K.; Jang, M.; Kim, G.H.; Ryoo, I.J.; Son, S.; Ryu, H.W.; Oh, S.R.; Lee, W.K.; Kim, B.Y.; Jang, J.H.; Ahn, J.S.
    Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity (2019), J. Enzyme Inhib. Med. Chem., 34, 1481-1488 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
F185A mutation eliminates activity of the enzyme Homo sapiens
P182A mutation eliminates activity of the enzyme Homo sapiens
P182A/F185A mutation eliminates activity of the enzyme Homo sapiens
P314A mutation increases IC50 for kushenol E Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(-)-kurarinone non-competitive inhibitor Homo sapiens
(2S)-2'-methoxy kurarinone non-competitive inhibitor Homo sapiens
1-methyl-tryptophan non-competitive inhibitor Homo sapiens
kushenol E non-competitive inhibitor, the inhibitor might be useful in the development of immunotherapeutic agents against cancers Homo sapiens
kushenol F non-competitive inhibitor Homo sapiens
noranhydroicaritin non-competitive inhibitor Homo sapiens
sophoraflavanone B non-competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO1
-
 Homo sapiens
indoleamine 2,3-dioxygenase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0077
-
 pH 6.5, 37°C Homo sapiens kushenol E
0.0193
-
 pH 6.5, 37°C Homo sapiens sophoraflavanone B
0.0234
-
 pH 6.5, 37°C Homo sapiens (-)-kurarinone
0.0235
-
 pH 6.5, 37°C Homo sapiens noranhydroicaritin
0.0254
-
 pH 6.5, 37°C Homo sapiens kushenol F
0.0314
-
 pH 6.5, 37°C Homo sapiens (2S)-2'-methoxy kurarinone
0.4233
-
 pH 6.5, 37°C Homo sapiens 1-methyl-tryptophan

General Information

General Information Comment Organism
drug target the enzyme is a tumour cell survival factor that causes immune escape in several types of cancer Homo sapiens
metabolism the enzyme is a tumour cell survival factor that causes immune escape in several types of cancer Homo sapiens