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Literature summary for 1.13.11.52 extracted from
- Kynurenine pathway metabolites and enzymes involved in redox reactions (2017), Neuropharmacology, 112, 331-345 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
L-tryptophan | pH and temperature not specified in the publication | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P14902 | - |
- |
| Homo sapiens | Q6ZQW0 | - |
- |
| Mus musculus | P28776 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
| astrocyte | - |
Homo sapiens | - |
| brain | expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes | Mus musculus | - |
| brain | expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes | Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| large intestine | - |
Mus musculus | - |
| large intestine | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | low level expression | Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| macrophage | - |
Mus musculus | - |
| macrophage | - |
Homo sapiens | - |
| microglia | - |
Mus musculus | - |
| microglia | - |
Homo sapiens | - |
| additional information | in human tumors IDO-2 is expressed, but it is produced in a functionally inactive form | Homo sapiens | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| placenta | - |
Mus musculus | - |
| placenta | - |
Homo sapiens | - |
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Homo sapiens | - |
| spleen | - |
Mus musculus | - |
| spleen | - |
Homo sapiens | - |
| stomach | - |
Mus musculus | - |
| stomach | - |
Homo sapiens | - |
| testis | low level expression | Homo sapiens | - |
| thyroid | low level expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
| L-tryptophan + O2 | the enzyme has broad substrate specificity for various indoleamines such as L-tryptophan and serotonin. It catalyzes the oxidation of the pyrrole ring of tryptophan to form N-formylkynurenine, which is later metabolized to formic acid and kynurenine | Mus musculus | N-formyl-L-kynurenine | - |
? | |
| L-tryptophan + O2 | the enzyme has broad substrate specificity for various indoleamines such as L-tryptophan and serotonin. It catalyzes the oxidation of the pyrrole ring of tryptophan to form N-formylkynurenine, which is later metabolized to formic acid and kynurenine | Homo sapiens | N-formyl-L-kynurenine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO-1 | - |
Mus musculus |
| IDO-1 | - |
Homo sapiens |
| IDO-2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | heme-containing enzyme | Mus musculus | |
| heme | heme-containing enzyme | Homo sapiens | |
| heme | the enzyme is heme dependent, requiring the reduction of ferric to ferrous-iron to bind to L-tryptophan | Homo sapiens | |
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