Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-DL-tryptophan | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Homo sapiens | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | - |
Homo sapiens | - |
additional information | indoleamine 2,3-dioxygenase is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells through the inhibition of aerobic glycolysis or through downregulation of key enzymes that directly or indirectly promote fatty acid synthesis, a prerequisite for CD4+ T-cell proliferation and differentiation into effector cell lineages | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells. Indoleamine 2,3-dioxygenase is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells through the inhibition of aerobic glycolysis or through downregulation of key enzymes that directly or indirectly promote fatty acid synthesis, a prerequisite for CD4+ T-cell proliferation and differentiation into effector cell lineages. IDO activates GCN2 kinase which inhibits CD4+ T-cell proliferation | Homo sapiens |