Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoic acid | EC50 is 183 nm | Homo sapiens | |
4-(methanesulfonyl)-N'-(3-methylphenyl)benzene-1-sulfonohydrazide | EC5 is 7846 nm | Homo sapiens | |
4-bromo-N'-(4-bromophenyl)benzene-1-sulfonohydrazide | EC50 is 374 nm | Homo sapiens | |
4-cyano-N'-(3-methylphenyl)benzene-1-sulfonohydrazide | EC50 is 3404 nm | Homo sapiens | |
4-[2-(4-bromophenyl)hydrazinesulfonyl]benzoic acid | EC50 is 172 nm | Homo sapiens | |
methyl 3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoate | EC50 is 465 nm | Homo sapiens | |
additional information | structure-activity relationships of phenyl benzenesulfonylhydrazides as indoleamine 2,3-dioxygenase inhibitors, overview. Coupling reactions between various benzenesulfonyl chlorides and phenylhydrazides are utilized to synthesize the sulfonylhydrazides bearing various substituents. EC50 values, overview | Homo sapiens | |
N'-(3-methylphenyl)-4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzene-1-sulfonohydrazide | EC50 is 296 nm | Homo sapiens | |
N'-(4-bromophenyl)-4-cyanobenzene-1-sulfonohydrazide | EC50 is 134 nm | Homo sapiens | |
N'-(4-bromophenyl)-4-methoxybenzene-1-sulfonohydrazide | EC50 is 640 nm | Homo sapiens | |
N'-(4-bromophenyl)benzenesulfonohydrazide | EC50 is 128 nm | Homo sapiens | |
N-(4-[2-[4-(trifluoromethyl)phenyl]hydrazinesulfonyl]phenyl)acetamide | EC50 is 181 nm | Homo sapiens | |
N-[4-(2-phenylhydrazinesulfonyl)phenyl]acetamide | EC50 is over 0.010 mM | Homo sapiens | |
N-[4-[2-(2,4-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is over 0.010 mM | Homo sapiens | |
N-[4-[2-(3,4-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 350 nm | Homo sapiens | |
N-[4-[2-(3,5-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 508 nm | Homo sapiens | |
N-[4-[2-(3,5-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 2229 nm | Homo sapiens | |
N-[4-[2-(3-bromo-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 2494 nm | Homo sapiens | |
N-[4-[2-(3-bromophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 7563 nm | Homo sapiens | |
N-[4-[2-(3-chloro-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 2588 nm | Homo sapiens | |
N-[4-[2-(3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is over 0.010 mM | Homo sapiens | |
N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]benzoyl]glycine | EC50 is 571 nm | Homo sapiens | |
N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 241 nm | Homo sapiens | |
N-[4-[2-(4-bromo-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 187 nm | Homo sapiens | |
N-[4-[2-(4-bromo-3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 130 nm | Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 85 nm | Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]butanamide | EC50 is 187 nm | Homo sapiens | |
N-[4-[2-(4-chloro-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 84 nm | Homo sapiens | |
N-[4-[2-(4-chlorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 142 nm | Homo sapiens | |
N-[4-[2-(4-cyanophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 1393 nm | Homo sapiens | |
N-[4-[2-(4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 609 nm | Homo sapiens | |
N-[4-[2-(4-methoxyphenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is over 0.010 mM | Homo sapiens | |
N-[4-[2-(4-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 1171 nm | Homo sapiens | |
N-[4-[2-(4-sulfamoylphenyl)hydrazinesulfonyl]phenyl]acetamide | EC50 is 3118 nm | Homo sapiens | |
[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenoxy]acetic acid | EC50 is 152 nm | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Homo sapiens | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000043 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(methanesulfonyl)-N'-(3-methylphenyl)benzene-1-sulfonohydrazide | |
0.000049 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000051 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000058 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromo-3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000059 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-cyano-N'-(3-methylphenyl)benzene-1-sulfonohydrazide | |
0.000059 | - |
pH and temperature not specified in the publication | Homo sapiens | N'-(3-methylphenyl)-4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzene-1-sulfonohydrazide | |
0.000061 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[2-(4-bromophenyl)hydrazinesulfonyl]benzoic acid | |
0.000071 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(2-phenylhydrazinesulfonyl)phenyl]acetamide | |
0.000079 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.00008 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]benzoyl]glycine | |
0.000085 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-bromo-N'-(4-bromophenyl)benzene-1-sulfonohydrazide | |
0.00011 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-chloro-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000121 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl 3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoate | |
0.000122 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000125 | - |
pH and temperature not specified in the publication | Homo sapiens | [4-[2-(4-bromophenyl)hydrazinesulfonyl]phenoxy]acetic acid | |
0.000128 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-bromo-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.00013 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000132 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]butanamide | |
0.000141 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoic acid | |
0.000155 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-chlorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000172 | - |
pH and temperature not specified in the publication | Homo sapiens | N'-(4-bromophenyl)benzenesulfonohydrazide | |
0.000176 | - |
pH and temperature not specified in the publication | Homo sapiens | N'-(4-bromophenyl)-4-cyanobenzene-1-sulfonohydrazide | |
0.000194 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-chloro-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000205 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromo-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000247 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3,4-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000254 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-methoxyphenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000255 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3-bromophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000352 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3,5-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.000608 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(2,4-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.001431 | - |
pH and temperature not specified in the publication | Homo sapiens | N'-(4-bromophenyl)-4-methoxybenzene-1-sulfonohydrazide | |
0.001605 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-[2-[4-(trifluoromethyl)phenyl]hydrazinesulfonyl]phenyl)acetamide | |
0.001746 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(3,5-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.002475 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-sulfamoylphenyl)hydrazinesulfonyl]phenyl]acetamide | |
0.005667 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-cyanophenyl)hydrazinesulfonyl]phenyl]acetamide |