Cloned (Comment) | Organism |
---|---|
quantitative real-time RT PCR enzyme expression analysis | Mus musculus |
quantitative real-time RT PCR enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | Alzheimer's disease brain | Homo sapiens | - |
brain | enzyme activity in triple transgenic Alzheimer's disease mice. Expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain | Mus musculus | - |
brain cortex | - |
Mus musculus | - |
brain cortex | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
hippocampus | - |
Mus musculus | - |
hippocampus | expression of TDO mRNA is significantly increased in the hippocampus of Alzheimer's disease patient brain. TDO co-localizes with quinolinic acid, neurofibrillary tangles-tau and amyloid deposits in the hippocampus of Alzheimer's disease patient brain | Homo sapiens | - |
additional information | quantitative real-time RT PCR enzyme expression analysis in brain sectiions | Mus musculus | - |
additional information | quantitative real-time RT PCR enzyme expression analysis in brain sectiions | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TDO | - |
Mus musculus |
TDO | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the kynurenine pathway is over-activated in Alzheimer's disease mice | Mus musculus |
metabolism | tryptophan 2,3 dioxygenase is the key regulatory enzyme of the kynurenine pathway | Mus musculus |
metabolism | tryptophan 2,3 dioxygenase is the key regulatory enzyme of the kynurenine pathway | Homo sapiens |