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Literature summary for 1.13.11.52 extracted from

  • Ohira, K.; Hagihara, H.; Toyama, K.; Takao, K.; Kanai, M.; Funakoshi, H.; Nakamura, T.; Miyakawa, T.
    Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus (2010), Mol. Brain, 3, 26.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dentate gyrus
-
 Mus musculus
-
granule cell mature granule cells of the adult mouse dentate gyrus Mus musculus
-
hippocampus
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
TDO
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus in mice heterozygous for the alpha-isoform of calcium/calmodulin-dependent protein kinase II, in which dentate gyrus granule cells fail to mature normally, TDO immunoreactivity is substantially downregulated in the dentate gyrus granule cells down
Mus musculus TDO expression gradually increases with the development of granule cells. new neurons begin to express TDO between 2 and 4 weeks after the neurons are generated, when the axons and dendrites of the granule cells develop and synaptogenesis occurs up

General Information

General Information Comment Organism
physiological function TDO expression distinguishes stem cells from more differentiated cells among the granule cells of the adult mouse dentate gyrus. TDO is required at a late-stage of granule cell development, such as during axonal and dendritic growth, synaptogenesis and its maturation Mus musculus