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Literature summary for 1.13.11.52 extracted from

  • Orabona, C.; Grohmann, U.
    Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond (2011), Methods Mol. Biol., 677, 269-280.
    View publication on PubMed
Search for more literature for 1.13.11.52

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-hydroxy-L-tryptophan + O2 Homo sapiens
-
 N-formyl-5-hydroxy-L-kynurenine
-
 ?
D-tryptophan + O2 Homo sapiens
-
 N-formyl-D-kynurenine
-
 ?
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?
serotonin + O2 Homo sapiens
-
 ?
-
 ?
tryptamine + O2 Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-L-tryptophan + O2
-
 Homo sapiens N-formyl-5-hydroxy-L-kynurenine
-
 ?
D-tryptophan + O2
-
 Homo sapiens N-formyl-D-kynurenine
-
 ?
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
serotonin + O2
-
 Homo sapiens ?
-
 ?
tryptamine + O2
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 42000-45000 Homo sapiens

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism IDO is the first and rate-limiting enzyme in the kynurenine pathway Homo sapiens
physiological function IDO is involved in the maintenance of immune tolerance at the maternal-fetal interface Homo sapiens