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Literature summary for 1.13.11.52 extracted from
- EPR and Moessbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase (2010), J. Am. Chem. Soc., 132, 1098-1109.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Cupriavidus metallidurans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | Cupriavidus metallidurans | - |
N-formyl-L-kynurenine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cupriavidus metallidurans | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Superdex 200 gel filtration | Cupriavidus metallidurans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Cupriavidus metallidurans | N-formyl-L-kynurenine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | x-ray crystallography | Cupriavidus metallidurans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDO | - |
Cupriavidus metallidurans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Cupriavidus metallidurans | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | tryptophan 2,3-dioxygenase is an essential enzyme in the pathway of NAD biosynthesis | Cupriavidus metallidurans |
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