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Literature summary for 1.13.11.52 extracted from
- Oren-gedoku-to and its constituents with therapeutic potential in Alzheimers disease inhibit indoleamine 2, 3-dioxygenase activity in vitro (2010), J. Alzheimers Dis., 22, 257-266.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Methyltryptophan | - |
Homo sapiens |  |
| baicalein | uncompetitive reversible potent IDO-1 inhibitor | Homo sapiens | |
| Berberine | uncompetitive reversible potent IDO-1 inhibitor | Homo sapiens | |
| Jatrorrhizine | irreversible potent IDO-1 inhibitor | Homo sapiens | |
| additional information | the traditional Chinese medicinal prescription Oren-gedoku-to significantly inhibits recombinant human IDO-1 activity in vitro | Homo sapiens | |
| palmatine | irreversible potent IDO-1 inhibitor | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO-1 | - |
Homo sapiens |
| indoleamine 2, 3-dioxygenase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
Berberine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.215 | - |
baicalein | pH and temperature not specified in the publication | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0093 | - |
pH and temperature not specified in the publication | Homo sapiens | Berberine | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | IDO-1 is one of the key players involved in the pathogenesis of Alzheimer's disease | Homo sapiens |
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