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Literature summary for 1.13.11.52 extracted from

  • Peng, K.; Monack, D.M.
    Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs (2010), Infect. Immun., 78, 2723-2733.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO1
-
 Mus musculus
indoleamine 2,3-dioxygenase 1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus isozyme IDO 1 (but not isozyme IDO2) is induced specifically in the lungs of mice infected with Francisella novicida or Streptococcus pneumonia up

General Information

General Information Comment Organism
malfunction the attenuation of Francisella novicida tryptophan mutant bacteria is rescued in the lungs of IDO1-deficient mice Mus musculus
physiological function indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs Mus musculus