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Literature summary for 1.13.11.52 extracted from

  • Soerensen, R.B.; Hadrup, S.R.; Svane, I.M.; Hjortso, M.C.; Thor Straten, P.; Andersen, M.H.
    Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators (2011), Blood, 117, 2200-2210.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD8+ cell
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens TLR9 ligand CpG, soluble CTLA4 or interferon-gamma induce IDO expression up

General Information

General Information Comment Organism
physiological function IDO is an immunoregulatory enzyme that is implicated in suppressing T-cell immunity in normal and pathological settings. IDO5-specific T cells are specifically able to kill IDO-expressing cells. IDO-specific T cells boost viral immunity Homo sapiens