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Literature summary for 1.13.11.52 extracted from

  • Jung, I.D.; Lee, J.S.; Lee, C.M.; Noh, K.T.; Jeong, Y.I.; Park, W.S.; Chun, S.H.; Jeong, S.K.; Park, J.W.; Son, K.H.; Heo, D.R.; Lee, M.G.; Shin, Y.K.; Kim, H.W.; Yun, C.H.; Park, Y.M.
    Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation (2010), Biochem. Pharmacol., 80, 491-505.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-D-tryptophan
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived dendritic cell
-
Mus musculus
-
dendritic cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
Mus musculus N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus IDO expression is abrogated by the heme oxygenase inhibitor zinc protoporphrin (5 mg/kg, i.p.). Heme oxygenase-1 downregulation decreases lipopolysaccharide-induced IDO expression in murine dendritic cells. Lipopolysaccharide induces high IDO expression down
Mus musculus IDO expression in bone marrow-derived dendritic cells is increased by hemin, a potent inducer of heme oxygenase-1 up

General Information

General Information Comment Organism
malfunction IDO deficiency leads to diminished phenotypic and functional maturation of dendritic cells in vitro and in vivo Mus musculus
metabolism IDO is a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation Mus musculus