Literature summary for 1.13.11.52 extracted from

Lu, C.; Lin, Y.; Yeh, S.R.
Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase (2009), J. Am. Chem. Soc., 131, 12866-12867.

Search for more literature for 1.13.11.52

Activating Compound

Activating Compound	Comment	Organism	Structure
1-(1H-indol-3-yl)ethanol	effector	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-methyl-L-tryptophan	substrate inhibition, 1-methyl-D-tryptophan exhibits no inhibitory effect	Homo sapiens
L-tryptophan	substrate inhibition	Homo sapiens
mitomycin C	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	L-tryptophan	-	Homo sapiens
0.015	-	L-tryptophan	in the presence of 5.1 mM 3-indole ethanol	Homo sapiens
0.016	-	L-tryptophan	in the presence of 2.5 mM 3-indole ethanol	Homo sapiens
0.042	-	O2	-	Homo sapiens
0.062	-	1-methyl-L-tryptophan	-	Homo sapiens
2.6	-	D-tryptophan	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-methyl-L-tryptophan + O2	-	Homo sapiens	?	-	?
D-tryptophan + O2	-	Homo sapiens	N-formyl-D-kynurenine	-	?
L-tryptophan + O2	-	Homo sapiens	N-formylkynurenine	-	?

Synonyms

Synonyms	Comment	Organism
indoleamine 2,3-dioxygenase	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.064	-	1-methyl-L-tryptophan	-	Homo sapiens
2.9	-	O2	-	Homo sapiens
3.1	-	L-tryptophan	-	Homo sapiens
3.2	-	L-tryptophan	in the presence of 2.5 mM 3-indole ethanol	Homo sapiens
3.5	-	L-tryptophan	in the presence of 5.1 mM 3-indole ethanol	Homo sapiens
5.9	-	D-tryptophan	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.032	-	1-methyl-L-tryptophan	-	Homo sapiens

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Release 2023.1 (January 2023)