Literature summary for 1.13.11.52 extracted from

Yuasa, H.J.; Ball, H.J.; Ho, Y.F.; Austin, C.J.; Whittington, C.M.; Belov, K.; Maghzal, G.J.; Jermiin, L.S.; Hunt, N.H.
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials (2009), Comp. Biochem. Physiol. B, 153, 137-144.

Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293T cell	Mus musculus
GST-fusioned protein, expressed in Escherichia coli, expressed in HEK-293T cell	Xenopus laevis
GST-fusioned protein, expressed in Escherichia coli, expressed in HEK-293T cell	Danio rerio
hexahistidyl tagged, expressed in Escherichia coli, expressed in HEK-293T cell	Ornithorhynchus anatinus
hexahistidyl tagged, expressed in Escherichia coli, expressed in HEK-293T cell	Monodelphis domestica

Protein Variants

Protein Variants	Comment	Organism
H339A	used as negative control	Xenopus laevis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0063	-	L-tryptophan	-	Monodelphis domestica
0.0191	-	L-tryptophan	-	Mus musculus
0.0537	-	L-tryptophan	-	Ornithorhynchus anatinus
11.7	-	L-tryptophan	-	Xenopus laevis
28.2	-	L-tryptophan	-	Danio rerio
54.1	-	L-tryptophan	-	Mus musculus
60.7	-	L-tryptophan	-	Monodelphis domestica
62.4	-	L-tryptophan	-	Ornithorhynchus anatinus

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-
Monodelphis domestica	B3Y9H8	XM_001381865: predicted coding sequences from genomic sequences	-
Monodelphis domestica	B3Y9H9	also another splice-variant detected, XM_001381868: predicted coding sequences from genomic sequences	-
Mus musculus	-	-	-
Ornithorhynchus anatinus	B3Y9H6	XM_001516468, XM_001521552: predicted coding sequences from genomic sequences	-
Ornithorhynchus anatinus	B3Y9H7	XM_001516116: predicted coding sequences from genomic sequences	-
Xenopus laevis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Xenopus laevis
-	Danio rerio
-	Ornithorhynchus anatinus
-	Monodelphis domestica

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Ornithorhynchus anatinus	-
liver	-	Monodelphis domestica	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Mus musculus	N-formylkynurenine	-	?
L-tryptophan + O2	-	Xenopus laevis	N-formylkynurenine	-	?
L-tryptophan + O2	-	Danio rerio	N-formylkynurenine	-	?
L-tryptophan + O2	-	Ornithorhynchus anatinus	N-formylkynurenine	-	?
L-tryptophan + O2	-	Monodelphis domestica	N-formylkynurenine	-	?

Synonyms

Synonyms	Comment	Organism
indoleamine 2,3-dioxygenase	-	Mus musculus
indoleamine 2,3-dioxygenase	-	Ornithorhynchus anatinus
indoleamine 2,3-dioxygenase	-	Monodelphis domestica
indoleamine 2,3-dioxygenase-2	-	Mus musculus
indoleamine 2,3-dioxygenase-2	-	Xenopus laevis
indoleamine 2,3-dioxygenase-2	-	Danio rerio
indoleamine 2,3-dioxygenase-2	-	Ornithorhynchus anatinus
indoleamine 2,3-dioxygenase-2	-	Monodelphis domestica
proto-indoleamine 2,3-dioxygenase	-	Mus musculus
proto-indoleamine 2,3-dioxygenase	-	Xenopus laevis
proto-indoleamine 2,3-dioxygenase	-	Danio rerio
proto-indoleamine 2,3-dioxygenase	-	Ornithorhynchus anatinus
proto-indoleamine 2,3-dioxygenase	-	Monodelphis domestica

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.9	-	L-tryptophan	-	Monodelphis domestica
1.8	-	L-tryptophan	-	Mus musculus
2.2	-	L-tryptophan	-	Xenopus laevis
2.6	-	L-tryptophan	-	Danio rerio
2.9	-	L-tryptophan	-	Ornithorhynchus anatinus
4.3	-	L-tryptophan	-	Ornithorhynchus anatinus
16.8	-	L-tryptophan	-	Mus musculus
19	-	L-tryptophan	-	Monodelphis domestica

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Release 2023.1 (January 2023)