Literature summary for 1.13.11.52 extracted from

Rafice, S.A.; Chauhan, N.; Efimov, I.; Basran, J.; Raven, E.L.
Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase (2009), Biochem. Soc. Trans., 37, 408-412.

Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment)	Organism
C-terminal hexahistidine tag, expressed in Escherichia coli	Homo sapiens
expressed in Escherichia coli	Homo sapiens
expressed in Escherichia coli	Xanthomonas campestris
expressed in Escherichia coli	Cupriavidus metallidurans

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Homo sapiens
-	Xanthomonas campestris
-	Cupriavidus metallidurans

Protein Variants

Protein Variants	Comment	Organism
S167H	active site, mimic tryptophan 2,3-oxigenase	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.01	-	L-tryptophan	-	Homo sapiens
0.114	-	L-tryptophan	-	Xanthomonas campestris
0.222	-	L-tryptophan	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
120000	-	about 120000 Da in prokaryotes	Xanthomonas campestris
120000	-	about 120000 Da in prokaryotes	Cupriavidus metallidurans
190000	-	about 190000 Da in eukaryotes	Drosophila melanogaster
190000	-	about 190000 Da in eukaryotes	Homo sapiens
190000	-	about 190000 Da in eukaryotes	Saccharomyces cerevisiae
190000	-	about 190000 Da in eukaryotes	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Cupriavidus metallidurans	-	-	-
Drosophila melanogaster	-	-	-
Homo sapiens	-	-	-
Mus musculus	-	-	-
Oryctolagus cuniculus	-	-	-
Saccharomyces cerevisiae	-	-	-
Xanthomonas campestris	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorotryptophan + O2	-	Homo sapiens	?	-	?
5-hydroxytryptamine + O2	-	Homo sapiens	?	-	?
5-hydroxytryptophan + O2	-	Homo sapiens	?	-	?
5-methyltryptophan + O2	-	Homo sapiens	?	-	?
6-fluorotryptophan + O2	-	Homo sapiens	?	-	?
D-tryptophan + O2	-	Homo sapiens	?	-	?
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?
L-tryptophan + O2	-	Drosophila melanogaster	N-formylkynurenine	-	?
L-tryptophan + O2	-	Mus musculus	N-formylkynurenine	-	?
L-tryptophan + O2	-	Homo sapiens	N-formylkynurenine	-	?
L-tryptophan + O2	-	Saccharomyces cerevisiae	N-formylkynurenine	-	?
L-tryptophan + O2	-	Oryctolagus cuniculus	N-formylkynurenine	-	?
L-tryptophan + O2	-	Xanthomonas campestris	N-formylkynurenine	-	?
L-tryptophan + O2	-	Cupriavidus metallidurans	N-formylkynurenine	-	?
tryptamine + O2	-	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
monomer	about 45000 Da	Homo sapiens
tetramer	-	Drosophila melanogaster
tetramer	-	Mus musculus
tetramer	-	Homo sapiens
tetramer	-	Saccharomyces cerevisiae
tetramer	-	Oryctolagus cuniculus
tetramer	-	Xanthomonas campestris
tetramer	-	Cupriavidus metallidurans

Synonyms

Synonyms	Comment	Organism
indoleamine 2,3-dioxygenase	-	Homo sapiens
tryptophan 2,3-dioxygenase	-	Drosophila melanogaster
tryptophan 2,3-dioxygenase	-	Mus musculus
tryptophan 2,3-dioxygenase	-	Homo sapiens
tryptophan 2,3-dioxygenase	-	Saccharomyces cerevisiae
tryptophan 2,3-dioxygenase	-	Oryctolagus cuniculus
tryptophan 2,3-dioxygenase	-	Xanthomonas campestris
tryptophan 2,3-dioxygenase	-	Cupriavidus metallidurans

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.4	-	L-tryptophan	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Drosophila melanogaster
heme	-	Mus musculus
heme	-	Homo sapiens
heme	-	Saccharomyces cerevisiae
heme	-	Oryctolagus cuniculus
heme	-	Xanthomonas campestris
heme	-	Cupriavidus metallidurans

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Release 2023.1 (January 2023)