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Literature summary for 1.13.11.52 extracted from

  • Liao, M.; Pabarcus, M.K.; Wang, Y.; Hefner, C.; Maltby, D.A.; Medzihradszky, K.F.; Salas-Castillo, S.P.; Yan, J.; Maher, J.J.; Correia, M.A.
    Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor (2007), J. Pharmacol. Exp. Ther., 323, 979-989.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Rattus norvegicus rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic determinant N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary hepatocyte Rattus norvegicus
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liver
-
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2 rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic determinant Rattus norvegicus N-formyl-L-kynurenine
-
?

Cofactor

Cofactor Comment Organism Structure
heme TDO is regulated by heme, its prosthetic moiety, as its expression and function are significantly reduced after acute hepatic heme depletion Rattus norvegicus