Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-phenylimidazole | heme ligand, non competitive, 0.1 M potassium phosphate buffer (pH 5.5-8), 0.1 M Tris-HCl buffer (pH 7.5-8), 25°C | Oryctolagus cuniculus | |
cyanide | heme ligand, competitive for the ferric enzyme | Oryctolagus cuniculus | |
D-tryptophan | - |
Oryctolagus cuniculus | |
norharman | non competitive, competitive for the ferric enzyme, 0.1 M potassium phosphate buffer (pH 5.5-8), 0.1 M Tris-HCl buffer (pH 7.5-8), 25°C | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.83 | - |
D-tryptophan | 0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25°C | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Oryctolagus cuniculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 8 | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
D-tryptophan | 0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25°C | Oryctolagus cuniculus |