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Literature summary for 1.13.11.52 extracted from
- Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation (1996), Adv. Exp. Med. Biol., 398, 285-289.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| diethyldithiocarbamate | inhibits superoxide dismutase | Oryctolagus cuniculus |  |
| Inosine | 0.1 mM, increases activity 5fold | Oryctolagus cuniculus | |
| additional information | not induced by either tryptophan or glucocorticoid | Oryctolagus cuniculus | |
| additional information | requires molecular oxygen and superoxide anion | Oryctolagus cuniculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Superoxide dismutase | can be inhibited by diethyldithiocarbamate | Oryctolagus cuniculus | |
| tyron | - |
Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-hydroxy-L-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-5-hydroxy-L-kynurenine | - |
? | |
| D-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-D-kynurenine | - |
? | |
| L-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-L-kynurenine | - |
? | |
| serotonin + O2 | Oryctolagus cuniculus | - |
? | - |
? | |
| tryptamine + O2 | Oryctolagus cuniculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-hydroxy-L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-5-hydroxy-L-kynurenine | - |
? | |
| D-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-D-kynurenine | - |
? | |
| L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? | |
| serotonin + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| tryptamine + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO | - |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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