Literature summary for 1.13.11.52 extracted from

Brady, F.O.; Monaco, M.E.; Forman, H.J.; Schutz, G.; Feigelson, P.
On the role of copper in activation of and catalysis by tryptophan-2,3-dioxygenase (1972), J. Biol. Chem., 247, 7915-7922.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Bathocuproinesulfonate	competitive with respect to L-Trp and noncompetitive with respect to O2	Delftia acidovorans
diethyldithiocarbamate	-	Delftia acidovorans
diethyldithiocarbamate	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	contains 2 gatom of copper per mol of enzyme	Rattus norvegicus
copper	contains 2 gatom of copper per mol of enzyme	Delftia acidovorans

Organism

Organism	UniProt	Comment	Textmining
Delftia acidovorans	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Delftia acidovorans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Rattus norvegicus
additional information	-	-	Delftia acidovorans

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Trp + O2	-	Rattus norvegicus	L-formylkynurenine	-	?
L-Trp + O2	-	Delftia acidovorans	L-formylkynurenine	-	?

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Delftia acidovorans
heme	2 mol of heme per tetramer	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.031	-	Bathocuproinesulfonate	-	Delftia acidovorans

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Release 2023.1 (January 2023)