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Literature summary for 1.13.11.52 extracted from

  • Yoshida, R.; Hayaishi, O.
    Overview: superoxygenase (1984), Methods Enzymol., 105, 61-70.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
superoxide the enzyme is inactive unless superoxide anion is present, the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
diethyldithiocarbamate 5 mM, markedly enhances activity Oryctolagus cuniculus
Superoxide dismutase
-
Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
copper only trace amounts of copper Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Trp + O2 Oryctolagus cuniculus a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon L-formylkynurenine
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein contains approximately 5% carbohydrate per weight Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Trp + O2 superoxide anion is required for the initiation of the reaction and the maintenance of the catalytic cycle during the steady state Oryctolagus cuniculus L-formylkynurenine
-
?
L-Trp + O2 a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon Oryctolagus cuniculus L-formylkynurenine
-
?

Cofactor

Cofactor Comment Organism Structure
heme the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme Oryctolagus cuniculus
heme 0.8 mol of protoheme IX per mol of enzyme Oryctolagus cuniculus