Activating Compound | Comment | Organism | Structure |
---|---|---|---|
superoxide | the enzyme is inactive unless superoxide anion is present, the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyldithiocarbamate | 5 mM, markedly enhances activity | Oryctolagus cuniculus | |
Superoxide dismutase | - |
Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | only trace amounts of copper | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | Oryctolagus cuniculus | a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon | L-formylkynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | contains approximately 5% carbohydrate per weight | Oryctolagus cuniculus |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | superoxide anion is required for the initiation of the reaction and the maintenance of the catalytic cycle during the steady state | Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
L-Trp + O2 | a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon | Oryctolagus cuniculus | L-formylkynurenine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme | Oryctolagus cuniculus | |
heme | 0.8 mol of protoheme IX per mol of enzyme | Oryctolagus cuniculus |