Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
homogentisate + O2 | Homo sapiens | - |
4-maleylacetoacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q93099 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | primary culture, alkaptonuria chondrocytes show a 10% increase of the enzyme expression compared to normal ones | Homo sapiens | - |
additional information | enzyme expression analysis in human normal and alkaptonuria chondrocytes, synoviocytes, osteoblasts as well as in human osteosarcoma cells, overview | Homo sapiens | - |
osteoarticular cell | - |
Homo sapiens | - |
osteoblast | - |
Homo sapiens | - |
synoviocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
homogentisate + O2 | - |
Homo sapiens | 4-maleylacetoacetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HgD | - |
Homo sapiens |
homogentisate 1,2 dioxygenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | alkaptonuria results from defective homogentisate1,2-dioxygenase, causing degenerative arthropathy. The deposition of ochronotic pigment in joints is so far attributed to homogentisic acid produced by the liver, circulating in the blood and accumulating locally. Alkaptonuria osteoarticular cells produce the ochronotic pigment in loco and this may strongly contribute to induction of ochronotic arthropath | Homo sapiens |