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Literature summary for 1.13.11.46 extracted from

  • Wojcik, A.; Broclawik, E.; Siegbahn, P.E.; Borowski, T.
    Mechanism of benzylic hydroxylation by 4-hydroxymandelate synthase. A computational study (2012), Biochemistry, 51, 9570-9580.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylpyruvate + O2 Amycolatopsis orientalis
-
 4-hydroxymandelate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Amycolatopsis orientalis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 HMS uses Fe(IV)=O to perform hydroxylation of the benzylic carbon, reaction mechanism with electrophilic attack on the aromatic ring, and HMS catalytic cycle, overview Amycolatopsis orientalis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
 Amycolatopsis orientalis 4-hydroxymandelate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2 active site structure and 4-hydroxymandelate binding structure, overview Amycolatopsis orientalis 4-hydroxymandelate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HMS
-
 Amycolatopsis orientalis
hydroxymandelate synthase
-
 Amycolatopsis orientalis

General Information

General Information Comment Organism
additional information molecular docking and modeling, molecular dynamics and simulations by classical molecular dynamics simulations, simulated HMS-Fe(IV)-O-HPA species, overview Amycolatopsis orientalis