Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.41 extracted from

  • Zhang, S.; Wang, X.; Liu, Y.
    Cleavage mechanism of the aliphatic C-C bond catalyzed by 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP a QM/MM study (2017), Catal. Sci. Technol., 7, 911-922 .
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ ha catalytic function and is coordinated by His76, His78, and His116, structure and catalytic mechanism, overview Alcaligenes sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,4'-dihydroxyacetophenone + O2 Alcaligenes sp.
-
4-hydroxybenzoate + formate
-
?
additional information Alcaligenes sp. enzyme DAD is very unusual in that it is involved in C-C bond cleavage in a substituent of the aromatic ring instead of cleaving within the aromatic ring of the substrate ?
-
?

Organism

Organism UniProt Comment Textmining
Alcaligenes sp. Q9REI7
-
-

Reaction

Reaction Comment Organism Reaction ID
2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate the cleavage mechanism of the aliphatic C-C bond catalyzed by 2,4'-dihydroxyacetophenone dioxygenase, quantum mechanics/molecular mechanics calculations. The reactant complex may firstly undergo a triplet-quintet crossing to initiate the reaction and then the subsequent chemistry mainly occurs on the quintet state surface, modeling of the enzyme-substrate complex, overview Alcaligenes sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4'-dihydroxyacetophenone + O2
-
Alcaligenes sp. 4-hydroxybenzoate + formate
-
?
additional information enzyme DAD is very unusual in that it is involved in C-C bond cleavage in a substituent of the aromatic ring instead of cleaving within the aromatic ring of the substrate Alcaligenes sp. ?
-
?

Synonyms

Synonyms Comment Organism
DAD
-
Alcaligenes sp.