Literature summary for 1.13.11.34 extracted from

Schieferdecker, S.; Koenig, S.; Koeberle, A.; Dahse, H.-M.; Werz, O.; Nett, M.
Myxochelins target human 5-lipoxygenase (2015), J. Nat. Prod., 78, 335-338 .

Search for more literature for 1.13.11.34

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	human 5-lipoxygenase (5-LO) is a molecular target of the myxochelins that have antiproliferative effects on K-562 and HeLa cancer cells	Homo sapiens
myxochelin A	isolated from extracts of the predatory myxobacterium Pyxidicoccus fallax HKI 727, IC50 values for inhibition of proliferative cells K-562 and HeLa are 0.3052 mM and 0.0039 mM, respectively	Homo sapiens
myxochelin C	isolated from extracts of the predatory myxobacterium Pyxidicoccus fallax HKI 727, IC50 values for inhibition of proliferative cells K-562 and HeLa are 0.424 mM and 0.0535 mM, respectively	Homo sapiens
myxochelin D	isolated from extracts of the predatory myxobacterium Pyxidicoccus fallax HKI 727, IC50 values for inhibition of proliferative cells K-562 and HeLa are above 0.5 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09917	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
K-562 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
5-lipoxygenase	-	Homo sapiens
5-LO	-	Homo sapiens

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Release 2023.1 (January 2023)