Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-LOX activating protein | - |
Homo sapiens | |
Nicotine | treatment with 0.01 mM nicotine activates 5-lipoxygenase gastric cancer cell lines from 36-72 h | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MK886 | 5-LOX activating protein inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | - |
leukotriene A4 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | - |
Homo sapiens | - |
MKN-28 cell | - |
Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LOX | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | blockade of 5-LOX signaling results in downregulation of cyclin D1, matrix metalloproteinase (MMP-7, -9), urokinase plasminogen activator and its receptor, and pro-apoptotic proteins | Homo sapiens |
physiological function | activation of 5-LOX modulates the G1/S phase transition regulatory proteins and causes cell proliferation | Homo sapiens |