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Literature summary for 1.13.11.34 extracted from

  • Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
    Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors (2008), Bioorg. Med. Chem., 16, 3907-3916.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 41% Homo sapiens
4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 31% Oryctolagus cuniculus
4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 51% Homo sapiens
4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 36% Oryctolagus cuniculus
4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 94% Homo sapiens
4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 36% Oryctolagus cuniculus
celecoxib 0.01 mM inhibits LOX-5 by 89% Homo sapiens
celecoxib 0.01 mM inhibits LOX-15 by 22% Oryctolagus cuniculus
rofecoxib 0.01 mM inhibits LOX-5 by 11% Homo sapiens
rofecoxib 0.01 mM inhibits LOX-15 by 6% Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information PBML cells Homo sapiens
-
reticulocyte LOX-15 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
arachidonate + O2
-
 Oryctolagus cuniculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
lipoxygenase 15
-
 Oryctolagus cuniculus
lipoxygenase 5
-
 Homo sapiens
LOX-15
-
 Oryctolagus cuniculus
LOX-5
-
 Homo sapiens