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Literature summary for 1.13.11.34 extracted from

  • Chinnici, C.M.; Yao, Y.; Pratico, D.
    The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old (2007), Neurobiol. Aging, 28, 1457-1462.
    View publication on PubMed
Search for more literature for 1.13.11.34

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus C57BL/6
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2 Mus musculus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
arachidonic acid + O2 Mus musculus C57BL/6
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P48999 C57BL/6 mice
-
Mus musculus C57BL/6 P48999 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview Mus musculus
-
cerebellum highest expresion of the enzyme in brain Mus musculus
-
cerebral cortex
-
 Mus musculus
-
hippocampus increased enzyme content in older rats, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O
-
 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2
-
 Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
arachidonic acid + O2
-
 Mus musculus C57BL/6 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Mus musculus
5-LO
-
 Mus musculus