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Literature summary for 1.13.11.34 extracted from

  • Massi, P.; Valenti, M.; Vaccani, A.; Gasperi, V.; Perletti, G.; Marras, E.; Fezza, F.; Maccarrone, M.; Parolaro, D.
    5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid (2008), J. Neurochem., 104, 1091-1100.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cannabidiol
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Hordeum vulgare
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2 Homo sapiens
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
arachidonic acid + O2 Hordeum vulgare
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Hordeum vulgare
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme to homogeneity from ungerminated seed Hordeum vulgare

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
Homo sapiens
-
additional information tissue specific expression analysis, overview Hordeum vulgare
-
seed ungerminated Hordeum vulgare
-
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Homo sapiens leukotriene A4 + H2O
-
?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Hordeum vulgare leukotriene A4 + H2O
-
?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Homo sapiens leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Hordeum vulgare leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
arachidonic acid + O2
-
Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
arachidonic acid + O2
-
Hordeum vulgare (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
Homo sapiens
5-lipoxygenase
-
Hordeum vulgare
5-LOX
-
Homo sapiens
5-LOX
-
Hordeum vulgare
arachidonate:oxygen oxidoreductase
-
Homo sapiens
arachidonate:oxygen oxidoreductase
-
Hordeum vulgare

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens