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Literature summary for 1.13.11.34 extracted from

  • Gubitosi-Klug, R.A.; Talahalli, R.; Du, Y.; Nadler, J.L.; Kern, T.S.
    5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy (2008), Diabetes, 57, 1387-1393.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information 5-LO-deficient mice show an inhibition of diabetes-induced acellular capillary formation in retina, and show reduced leukostasis and superoxide generation, diabetic enzyme-deficient mice show suppression of NF-kappaB expression, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus C57BL/6
-
leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
arachidonic acid + O2 Mus musculus
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
arachidonic acid + O2 Mus musculus C57BL/6
-
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
pericyte
-
Mus musculus
-
retina retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus leukotriene A4 + H2O
-
?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus C57BL/6 leukotriene A4 + H2O
-
?
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
Mus musculus C57BL/6 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
arachidonic acid + O2
-
Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?
arachidonic acid + O2
-
Mus musculus C57BL/6 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
Mus musculus