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Literature summary for 1.13.11.34 extracted from
- Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase (2005), Phytother. Res., 19, 81-102.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (-)-epicatechin | - |
Homo sapiens |  |
| 11alpha,13-dihydrohelenalin acetate | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| 2,3,4',5-tetrahydroxystilbene-2-O-D-glucoside | polymorphonuclear leukocyte | Rattus norvegicus | |
| 4-methylesculetin | polymorphonuclear leukocyte | Rattus norvegicus | |
| beta-hydroxyacteoside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| capsaicin | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| daphnetin | polymorphonuclear leukocyte | Rattus norvegicus | |
| esculetin | polymorphonuclear leukocyte | Rattus norvegicus | |
| falcarindiol | - |
Sus scrofa | |
| forsythiaside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| forsythiaside | polymorphonuclear leukocyte | Rattus norvegicus | |
| fraxetin | polymorphonuclear leukocyte | Rattus norvegicus | |
| gingerdione | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| helenalin | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| isoriccardin C | - |
Sus scrofa | |
| leucocyanidol | polymorphonuclear leukocyte | Rattus norvegicus | |
| marchantin A | - |
Sus scrofa | |
| marchantin B | - |
Sus scrofa | |
| marchantin D | - |
Sus scrofa | |
| marchantin E | - |
Sus scrofa | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases | Bos taurus | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Cavia porcellus | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Glycine max | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Helianthus tuberosus | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Mus musculus | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Rattus norvegicus | |
| additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Sus scrofa | |
| myrtol | enzyme from RBL-1 cell | Rattus norvegicus | |
| oroxindin | polymorphonuclear leukocyte | Rattus norvegicus | |
| paleatin B | - |
Sus scrofa | |
| panaxynol | - |
Sus scrofa | |
| perrottetin D | - |
Sus scrofa | |
| piceid | polymorphonuclear leukocyte | Rattus norvegicus | |
| quercetagetin-7-O-beta-D-glucoside | polymorphonuclear leukocyte | Rattus norvegicus | |
| radulanin H | - |
Sus scrofa | |
| resveratrol | polymorphonuclear leukocyte | Rattus norvegicus | |
| shogaol | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| sideritoflavone | polymorphonuclear leukocyte | Rattus norvegicus | |
| suspensaside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| suspensaside | polymorphonuclear leukocyte | Rattus norvegicus | |
| tambuletin | polymorphonuclear leukocyte | Rattus norvegicus | |
| verbascoside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
| verbascoside | polymorphonuclear leukocyte | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cavia porcellus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Mus musculus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Homo sapiens | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Rattus norvegicus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Sus scrofa | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Bos taurus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Glycine max | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
| additional information | Helianthus tuberosus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Glycine max | - |
- |
- |
| Helianthus tuberosus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Homo sapiens | - |
| granulocyte | - |
Homo sapiens | - |
| leukocyte | - |
Sus scrofa | - |
| macrophage | - |
Homo sapiens | - |
| mast cell | - |
Rattus norvegicus | - |
| neutrophil | - |
Homo sapiens | - |
| polymorphonuclear leukocyte | - |
Homo sapiens | - |
| polymorphonuclear leukocyte | - |
Rattus norvegicus | - |
| polymorphonuclear leukocyte | - |
Bos taurus | - |
| polymorphonuclear leukocyte | peritoneal | Cavia porcellus | - |
| polymorphonuclear leukocyte | peritoneal | Mus musculus | - |
| RBL-1 cell | basophilic leukemia cell | Rattus norvegicus | - |
| seedling | - |
Helianthus tuberosus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Cavia porcellus | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Mus musculus | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Homo sapiens | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Rattus norvegicus | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Sus scrofa | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Bos taurus | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Glycine max | ? | - |
? | |
| additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Helianthus tuberosus | ? | - |
? | |
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