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Literature summary for 1.13.11.34 extracted from

  • Schwarz, K.; Gerth, C.; Anton, M.; Kuhn, H.
    Alterations in Leukotriene Synthase Activity of the Human 5-Lipoxygenase by Site-Directed Mutagenesis Affecting Its Positional Specificity (2000), Biochemistry, 39, 14515-14521.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
F359W/A4241 8-lipoxygenating mutant Homo sapiens
F359W/A424I/N425M/A603I 15-lipoxygenating mutant Homo sapiens
F359W/A424I/N425M/A603I produces only minor amounts of leukotriene A4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate + minor amounts of the double oxygenation products ?