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Literature summary for 1.13.11.34 extracted from
- Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids (1986), J. Biol. Chem., 261, 7982-7988.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | stimulates | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AA861 | - |
Sus scrofa | |
| Cirsiliol | - |
Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
x * 72000, SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Sus scrofa | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 1 week, no appreciable inactivation | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (12S)hydroperoxy-5,8-cis-10-trans-13-cis-eicosatetraenoic acid + O2 | 22% of the activity with arachidonic acid | Sus scrofa | (5S,12S)-dihydroperoxy-5,8-cis-10-trans-13-cis-eicosatetraenoic acid | - |
? | |
| (15S)-hydroperoxy-5,8,11-cis-13-trans-eicosatetraenoic acid + O2 | 30% of the activity with arachidonic acid | Sus scrofa | (5S,15S)-dihydroperoxy-5,8,11-cis-13-trans-eicosatetraenoic acid | - |
? | |
| arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Sus scrofa | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | + leukotriene A4 | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000, SDS-PAGE | Sus scrofa |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 2 | - |
half-life: 24 h | Sus scrofa |
| 24 | - |
1 h, 50% loss of activity | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Sus scrofa |
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