Literature summary for 1.13.11.33 extracted from

Pelcman, B.; Sanin, A.; Nilsson, P.; Schaal, W.; Olofsson, K.; Krog-Jensen, C.; Forsell, P.; Hallberg, A.; Larhed, M.; Boesen, T.; Kromann, H.; Claesson, H.E.
N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase (2015), Bioorg. Med. Chem. Lett., 25, 3017-3023 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(3-chlorobenzoyl)-N-(2-chlorophenyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
1-acetyl-N-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
1-benzyl-N-(2-chlorophenyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
1-[(2H-1,3-benzodioxol-5-yl)carbamothioyl]-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
4-chlorophenyl 3-[(2-chlorophenyl)carbamoyl]-1H-pyrazole-1-carboxylate	-	Homo sapiens
5-butyl-N3-(2-chloro-4-fluorophenyl)-N1-hexyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
ethyl 6-([3-[(2-chloro-4-fluorophenyl)carbamoyl]-1H-pyrazole-1-carbonyl]amino)hexanoate	-	Homo sapiens
additional information	N-substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase, overview. No inhibition by 7h and 10a	Homo sapiens
N-(2-chloro-4-fluorophenyl)-1-(dimethylsulfamoyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
N-(2-chloro-4-fluorophenyl)-1-(phenylacetyl)-1H-pyrazole-3-carboxamide	-	Homo sapiens
N-(2-chloro-4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide	-	Homo sapiens
N-(2-chloro-4-fluorophenyl)-1-[3-(trifluoromethyl)benzene-1-sulfonyl]-1H-pyrazole-3-carboxamide	-	Homo sapiens
N1-(2H-1,3-benzodioxol-5-yl)-N-3-(2-chloro-4-fluorophenyl)-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
N1-butyl-N3-(2-chlorophenyl)-N3-methyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
N3-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-N1-hexyl-5-methyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
N3-(2-chloro-4-fluorophenyl)-N1-hexyl-4-methyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
N3-(2-chloro-4-fluorophenyl)-N1-pentyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens
N3-(2-chlorophenyl)-N1,N1-dimethyl-1H-pyrazole-1,3-dicarboxamide	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + O2	Homo sapiens	best substrate	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16050	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	best substrate	Homo sapiens	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase	-	Homo sapiens
15-lipoxygenase-1	-	Homo sapiens
15-LOX-1	-	Homo sapiens

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Release 2023.1 (January 2023)