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Literature summary for 1.13.11.33 extracted from

  • Dioszeghy, V.; Rosas, M.; Maskrey, B.H.; Colmont, C.; Topley, N.; Chaitidis, P.; Kuehn, H.; Jones, S.A.; Taylor, P.R.; ODonnell, V.B.
    12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo (2008), J. Immunol., 181, 6514-6524.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57BL/6 mice
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Mus musculus C57BL/6
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C57BL/6 mice
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage 12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo Mus musculus
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Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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Mus musculus
12/15-LOX
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Mus musculus

General Information

General Information Comment Organism
physiological function endogenous 12/15-LOX defines the resident peritoneal macrophage population and regulates both the recruitment of monocytes/peritoneal macrophage and cytokine response to bacterial products in vivo Mus musculus