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Literature summary for 1.13.11.33 extracted from

  • Yuan, H.; Lanting, L.; Xu, Z.; Li, S.; Swiderski, P.; Putta, S.; Jonnalagadda, M.; Kato, M.; Natarajan, R.
    Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes (2008), Am. J. Physiol. Renal Physiol., 295, F605-F617.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development systemic delivery of cholesterol-tagged siRNAs targeting 12/15-LO has renoprotective effects under diabetic conditions and therefore can be a novel therapeutic approach for diabetic nephropathy Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
siRNA cholesterol-tagged siRNAs targeting mouse leukocyte 12/15-LO reduce 12/15-LO expression in the kidney and confer beneficial effects on diabetes-induced changes in glomerular structure and ECM accumulation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 DBA/2J mice
-
Mus musculus DBA/2J
-
 DBA/2J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
leukocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-
spleen
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
-
 Mus musculus
12/15-LO
-
 Mus musculus