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Literature summary for 1.13.11.33 extracted from
- Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases (2007), Biochim. Biophys. Acta, 1770, 1062-1070.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics with lysophospholipid substrates | Oryctolagus cuniculus | |
| 0.0083 | - |
1-linoleoyl lysophosphatidic acid | pH 7.4, 25°C | Oryctolagus cuniculus |  |
| 0.0121 | - |
linoleic acid | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 0.0175 | - |
1-linoleoyl lysophosphatidylcholine | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 0.0717 | - |
dilinoleoyl phosphatidylcholine | pH 7.4, 25°C | Oryctolagus cuniculus | |
| 0.09 | - |
dilinoleoyl phosphatidic acid | pH 7.4, 25°C | Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | Oryctolagus cuniculus | - |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Oryctolagus cuniculus | - |
| reticulocyte | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.668 | - |
commercial preparation | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-linoleoyl lysophosphatidic acid + O2 | i.e. linoleoyl-lysoPA | Oryctolagus cuniculus | (S)-hydroperoxy 1-linoleoyl lysophosphatidic acid | major product | ? | |
| 1-linoleoyl lysophosphatidylcholine + O2 | i.e. linoleoyl-lysoPC | Oryctolagus cuniculus | (S)-hydroperoxy 1-linoleoyl lysophosphatidylcholine | major product | ? | |
| arachidonate + O2 | - |
Oryctolagus cuniculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
| dilinoleoyl phosphatidic acid + O2 | i.e. dilinoleoylPA | Oryctolagus cuniculus | (S)-hydroperoxy dilinoleoyl phosphatidic acid | - |
? | |
| dilinoleoyl phosphatidylcholine + O2 | i.e. dilinoleoylPC | Oryctolagus cuniculus | (S)-hydroperoxy dilinoleoyl phosphatidylcholine | - |
? | |
| linoleic acid + O2 | - |
Oryctolagus cuniculus | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| additional information | stereo-selectivity in LOX-catalyzed oxygenation of lysophospholipids, overview | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| reticulocyte-type 15-lipoxygenase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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