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Literature summary for 1.13.11.33 extracted from

  • Narumiya, S.; Salmon, J.A.
    Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes (1982), Methods Enzymol., 86, 45-48.
    View publication on PubMed

General Stability

General Stability Organism
repeated freezing and thawing causes a considerable loss of activity Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
5,8,11,14-Eicosatetraynoic acid
-
Oryctolagus cuniculus
BW755C
-
Oryctolagus cuniculus
iodoacetamide 1.0 mM, 30% inhibition Oryctolagus cuniculus
PCMB 0.1 mM, 30% inhibition Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
arachidonic acid
-
Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates reaction with crude extract Oryctolagus cuniculus
Mg2+ activates reaction with crude extract Oryctolagus cuniculus
Mn2+ activates reaction with crude extract Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
gel filtration Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Oryctolagus cuniculus first step in biotransformation of arachidonic acid to the 15-series of leukotrienes, reaction is involved in inactivation of slow-reacting substrances of anaphylaxis (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte peritoneal polymorphonuclear leukocytes Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
93.5
-
-
Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
-40°C, 1 month, 60% loss of activity Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate and nonenzymatic production of 15-hydroxy-5,8,11,13-eicosatetraenoic acid, 15-keto-5,8,11,13-eicosatetraenoic acid, 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid and 11,14,15-trihydroxy-5,8,12-eicosatrienoic acid ?
arachidonate + O2 first step in biotransformation of arachidonic acid to the 15-series of leukotrienes, reaction is involved in inactivation of slow-reacting substrances of anaphylaxis Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Oryctolagus cuniculus

pH Stability

pH Stability pH Stability Maximum Comment Organism
7
-
24 h, 30% loss of activity Oryctolagus cuniculus