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Literature summary for 1.13.11.31 extracted from

  • Ibrahim, A.S.; Tawfik, A.M.; Hussein, K.A.; Elshafey, S.; Markand, S.; Rizk, N.; Duh, E.J.; Smith, S.B.; Al-Shabrawey, M.
    Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids (2015), Biochim. Biophys. Acta, 1851, 290-298 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Mus musculus
-
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?
arachidonate + O2 Mus musculus C57BL/6J
-
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P39654
-
-
Mus musculus C57BL/6J P39654
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Mueller cell
-
Mus musculus
-
retina
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Mus musculus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?
arachidonate + O2
-
Mus musculus C57BL/6J (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
-
Mus musculus

General Information

General Information Comment Organism
physiological function 12/15-lipoxygenase derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor and pigment epithelium-derived factor. Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids, i.e. (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate, mechanism, overview. 12-HETE stimulates inflammatory cytokine production such as interleukin IL-6 and TNF-alpha from retinal Müller cells (rMCs) Mus musculus