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Literature summary for 1.13.11.31 extracted from

  • Kroenke, G.; Katzenbeisser, J.; Uderhardt, S.; Zaiss, M.M.; Scholtysek, C.; Schabbauer, G.; Zarbock, A.; Koenders, M.I.; Axmann, R.; Zwerina, J.; Baenckler, H.W.; van den Berg, W.; Voll, R.E.; Kuehn, H.; Joosten, L.A.; Schett, G.
    12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis (2009), J. Immunol., 183, 3383-3389.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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synovial tissue
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 Mus musculus
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Synonyms

Synonyms Comment Organism
12/15-LO
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 Mus musculus
leukocyte-type 12/15-lipoxygenase
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus strong expression of 12/15-LO in inflammatory synovial tissue up

General Information

General Information Comment Organism
physiological function anti-inflammatory and tissue-protective role of 12/15-LO and its eicosanoidic products during chronic inflammatory disorders such as arthritis. 12/15-LO-deficient mice show enhanced inflammatory gene expression and decreased levels of the eicosanoid lipoxin A(4) within their inflamed synovia. 12/15-LO-deficient macrophages display significantly reduced levels of lipoxin A(4), which correlate with increased activation of p38MAPK and an enhanced inflammatory gene expression after stimulation with TNF-alpha Mus musculus