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Literature summary for 1.13.11.31 extracted from

  • Yoo, H.; Jeon, B.; Jeon, M.S.; Lee, H.; Kim, T.Y.
    Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes (2008), FEBS Lett., 582, 3249-3253.
    View publication on PubMed
Search for more literature for 1.13.11.31

Application

Application Comment Organism
medicine psoralen plus ultraviolet A decreases 12-LOX expression, thus this UVA photochemotherapy is considered to be first-line treatment for patients with moderate to severe psoriasis. Interruption of 12-LOX catalytic activity and the 12-hydroxyeicosatetraenoic acid signaling pathway by increasing 15-LOX metabolites may be a promising target for psoriasis therapies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
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 Homo sapiens
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keratinocyte
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
12-lipoxygenase
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 Homo sapiens
12-LOX
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 Homo sapiens
12/15-lipoxygenase
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 Homo sapiens
12/15-LOX
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens level of 12-LOX expression is dose-dependently decreased by UVB and UVA-irradiation. Successful psoralen plus ultraviolet A, UVA-photochemotherapy-mediated inhibition of cell growth and inflammation via decreased 12-LOX expression. 15(S)-hydroxyeicosatetraenoic acid, 15-HETrE and 13(S)-hydroxyoctadecadienoic acid (15-LOX metabolites) significantly inhibit insulin-like growth factor II-induced 12-LOX expression down
Homo sapiens insulin-like growth factor II induces 12-LOX expression and blocks cell cycle progression up