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Literature summary for 1.13.11.31 extracted from
- Characterization of the murine epidermal 12/15-lipoxygenase (2001), Prostaglandins Other Lipid Mediat., 63, 93-107.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK 293 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
four 12-lipoxygenase: 1.platelet-type 12-lipoxygenase, 2. leukocyte-type lipoxygenase, 3. epidermal-type lipoxygenase, 4. 12(R)-lipoxygenase | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blastocyst | - |
Mus musculus | - |
| embryo | - |
Mus musculus | - |
| epidermis | - |
Mus musculus | - |
| oocyte | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, half-life: less than 1 h | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,7,10,13,16,19-docosahexaenoic acid + O2 | - |
Mus musculus | 14-hydroxy-4,7,10,12,16,19-docosahexaenoic acid | - |
? |  |
| 5,8,11,14,17-eicosapentaenoic acid + O2 | - |
Mus musculus | 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid | 12-hydroxyeicosapentaenoic acid | ? | |
| 6,9,12-octadecatrienoic acid + O2 | - |
Mus musculus | 13-hydroxy-6,9,12-octadecatrienoic acid | - |
? | |
| 8,11,14-eicosatrienoic acid + O2 | - |
Mus musculus | 12-hydroxyeicosatrienoic acid | - |
? | |
| arachidonate + O2 | i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid | Mus musculus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in the ratio of 6:1 | ? | |
| gamma-linolenic acid + O2 | - |
Mus musculus | 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 12(R)-lipoxygenase | - |
Mus musculus |
| epidermal-type lipoxygenase | - |
Mus musculus |
| leukocyte-type lipoxygenase | - |
Mus musculus |
| platelet-type 12-lipoxygenase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 37 | - |
Mus musculus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
half-life: less than 1 h | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 7.9 | - |
Mus musculus |
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