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Literature summary for 1.13.11.31 extracted from

  • Wallach, D.P.; Brown, V.R.
    A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases (1981), Biochim. Biophys. Acta, 663, 361-372.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzoyl chloride
-
Homo sapiens
chloroglyoxylic acid ethyl ester
-
Homo sapiens
isonicotinaldehyde
-
Homo sapiens
methyl-4-pyridyl ketone
-
Homo sapiens
nicotinoyl chloride
-
Homo sapiens
picolinaldehyde
-
Homo sapiens
pyruvoyl chloride
-
Homo sapiens
Sn2+ 3.7 mM, complete inhibition Homo sapiens
Zn2+ 3.7 mM, complete inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
5,8,11,14,17-eicosapentaenoic acid
-
Homo sapiens
0.079
-
8,11,14-eicosatrienoic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,8,11,14,17-eicosapentaenoic acid + O2
-
Homo sapiens 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
?
8,11,14-eicosatrienoic acid + O2
-
Homo sapiens 12-hydroxyeicosatrienoic acid
-
?
arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
-
-
loses appreciable activity when left overnight in an ice bath Homo sapiens
50
-
3 min, enzyme solubilized with 1% deoxycholate, 20% loss of activity Homo sapiens
65
-
3 min, enzyme solubilized with 1% deoxycholate, complete loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.5
-
Homo sapiens