Literature summary for 1.13.11.3 extracted from

Que, L.; Lipscomb, J.D.; Munck, E.; Wood, J.M.
Protocatechuate 3,4-dioxygenase. Inhibitor studies and mechanistic implications (1977), Biochim. Biophys. Acta, 485, 60-74.

Search for more literature for 1.13.11.3

Inhibitors

Inhibitors	Comment	Organism	Structure
2-Fluoro-4-hydroxybenzoate	-	Pseudomonas putida
3,4-Dihydroxyacetophenone	-	Pseudomonas putida
3,4-Dihydroxyphenylacetate	-	Pseudomonas putida
3,4-Dihydroxyphenylpropionate	-	Pseudomonas putida
3-Fluoro-4-hydroxybenzoate	-	Pseudomonas putida
3-hydroxybenzoate	-	Pseudomonas putida
4-Fluoro-3-hydroxybenzoate	-	Pseudomonas putida
4-hydroxybenzoate	-	Pseudomonas putida
4-hydroxymercuribenzoate	-	Pseudomonas putida
catechol	-	Pseudomonas putida
Isovanillate	-	Pseudomonas putida
Protocatechualdehyde	-	Pseudomonas putida
Protocatechuic acid methyl ester	-	Pseudomonas putida
vanillate	-	Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3,4-dihydroxybenzoate + O2	Pseudomonas putida	-	3-carboxy-cis,cis-muconate	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas putida	-	previously classified as Pseudomonas aeruginosa strain ATCC 23975	-

Reaction

Reaction	Comment	Organism	Reaction ID
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate	proposed mechanism based on Mössbauer, EPR and inhibition kinetic data	Pseudomonas putida	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-dihydroxybenzoate + O2	-	Pseudomonas putida	3-carboxy-cis,cis-muconate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.003	-	vanillate	-	Pseudomonas putida
0.004	-	3-hydroxybenzoate	-	Pseudomonas putida
0.01	-	3-Fluoro-4-hydroxybenzoate	-	Pseudomonas putida
0.01	-	2-Fluoro-4-hydroxybenzoate	-	Pseudomonas putida
0.013	-	3,4-Dihydroxyphenylacetate	-	Pseudomonas putida
0.014	-	Protocatechualdehyde	-	Pseudomonas putida
0.018	-	3,4-Dihydroxyphenylpropionate	-	Pseudomonas putida
0.02	-	Isovanillate	-	Pseudomonas putida
0.13	-	3,4-Dihydroxyacetophenone	-	Pseudomonas putida
0.24	-	4-hydroxybenzoate	-	Pseudomonas putida
0.4	-	protocatechuic acid methylester	-	Pseudomonas putida
0.7	-	catechol	-	Pseudomonas putida
0.8	-	4-Fluoro-3-hydroxybenzoate	-	Pseudomonas putida

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Release 2023.1 (January 2023)